The signal

Capture the whole gland, not 0.32% of it.

Standard prostate biopsy samples roughly 0.32% of the gland and misses disease in the rest. Garde measures 40 to 50 exosomal small non-coding RNA sequences shed by the entire gland into urine, capturing a whole-gland molecular fingerprint from a non-invasive sample.

The pipeline

From sample to actionable result.

A four-step pipeline that runs on the reference lab infrastructure healthcare systems already trust.

STEP 01

Start with urine

A standard, non-invasive urine sample. No biopsy, no needle, no catheter. Collected anywhere and shipped to a reference lab.

STEP 02

Extract biomarkers

A reference lab extracts, amplifies, and quantifies the biomarkers using established molecular biology techniques and standard laboratory tools.

STEP 03

Algorithmic analysis

A supervised machine learning model, trained on curated outcome-labeled cohorts, translates the molecular signal into a quantitative risk of clinically significant disease.

STEP 04

Actionable results

Garde Prostate Test results indicate which treatment pathway will best serve the patient. The test results are aligned to NCCN treatment and billing pathways.

The algorithm

Supervised machine learning, hosted on Garde infrastructure.

The molecular signal alone isn't a diagnosis. Clinicians need a calibrated, quantitative risk assessment that maps to existing care pathways. Garde's supervised machine learning model transforms the multi-marker sncRNA panel into a single, interpretable risk score for clinically significant disease.

PRINCIPLE 01

Multi-signal

Built on roughly 40 to 50 biomarker sequences read in parallel, capturing whole-gland biology rather than relying on a single noisy signal.

PRINCIPLE 02

Interpretable

Output maps directly to existing NCCN pathways. No new clinical workflow required.

PRINCIPLE 03

Improvable

As validation cohorts grow, the model improves without re-engineering the lab workflow.

Integration

Designed for the labs healthcare systems already use.

Garde slots into the reference lab infrastructure healthcare systems already trust. Sample prep follows established molecular biology techniques. Output is delivered through standard reporting interfaces. The clinical decision flows mirror the pathways urologists already use.

  • Standard collectionUrine sample, no novel hardware required for the patient or clinician.
  • Reference-lab compatibleSuppliers trusted by healthcare systems globally can purchase and process the test.
  • Existing care pathwaysResults route into NCCN treatment and billing pathways without disruption.

Garde owns the algorithm. The wet lab is commodity.

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